Yulia Nefedova

Dr. Yulia Nefedova is an Associate Professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute's Ellen and Ronald Caplan Cancer Center. She joined Wistar in 2013 as an assistant professor in the Tumor Microenvironment and Metastasis program, was promoted to associate professor in the Immunology, Microenvironment and Metastasis Program in 2017, and transitioned to her current position in the Molecular and Cellular Oncogenesis Program in 2024.

Dr. Nefedova's research focuses on understanding molecular mechanisms by which the bone marrow microenvironment promotes tumor survival and progression, with particular emphasis on multiple myeloma. Her laboratory investigates how interactions between bone marrow neutrophils and multiple myeloma cells promote disease progression and chemoresistance, with specific interest in neutrophil extracellular traps (NETs) and the S100A9 protein.

Analysis of her 15 most recent publications reveals a consistent focus on neutrophil biology within the tumor microenvironment, particularly their role in promoting cancer progression and therapy resistance. Her work spans immunology, cancer biology, and molecular oncology with increasing emphasis on therapeutic targeting of neutrophil-mediated processes.

Dr. Nefedova's laboratory includes Research Assistant Melissa Haddadi and Lab Assistants Hsuan-Yu Lin and Hannah Lee. She maintains active collaborations with prominent researchers including Dr. Dmitry Gabrilovich, as evidenced by their frequent co-authorship.