Yuhui Yin

Yuhui Yin is a Professor in the Department of Biochemistry & Molecular Biology at UTMB Health. Their research focuses on mitochondrial DNA polymerases, antiviral drug toxicity, and mechanisms of DNA replication/repair. Key areas include understanding how mitochondrial DNA replication interacts with antiviral therapies and developing vaccines against bacterial pathogens.

Education:

• PhD from University of North Carolina at Chapel Hill (Chapel Hill, North Carolina, US)
• MD from Tianjin Medical College (Tianjin, China)

Research Interests: Yin's work explores mitochondrial DNA polymerase γ's role in genome integrity, antiviral drug-induced mitochondrial toxicity, and structural biology of replication enzymes. They investigate how DNA polymerases balance fidelity and efficiency during replication, with implications for neurodegenerative diseases and cancer.

Grants/Projects:

• NIH R01GM145925 (2023-2027): Studies mitochondrial translesion DNA synthesis
• NIH R01AI134611 (2018-2023): Investigates antiviral drug toxicity mechanisms
• NIH Support (2012-2015): Explored HIV-RT inhibitors' effects on human mitochondrial DNA polymerase

Labs/Teams: Leads a research group focused on structural enzymology and mitochondrial biology, collaborating internationally on vaccine development and drug toxicity studies.