معرفی
Yuhua Song is a Professor in the Department of Biomedical Engineering at the University of Alabama at Birmingham (UAB). She joined UAB in 2006 as an Assistant Professor after working as a research instructor at Washington University in St. Louis' Department of Biochemistry and Molecular Biophysics and Center for Computational Biology.
Dr. Song's educational background includes:
- B.S. in Materials Science & Engineering from Jilin University of Technology
- M.S. in Materials Science & Engineering from Harbin University of Science and Technology
- Ph.D. in Materials Science & Engineering from Harbin Institute of Technology
- Post-Doctoral training in Computational Mechanics at Tsinghua University
- Post-Doctoral training in Computational Biomechanics at University of Pittsburgh
- Post-Doctoral training in Computational Biology at Washington University in St. Louis
Dr. Song's research focuses on integrated computational and experimental approaches to study biomolecular modeling, biomechanics, and biomolecular interactions. Her work particularly emphasizes ligand identification and drug repositioning for therapeutic applications. She employs multiscale computational modeling to investigate structural, molecular and functional mechanisms of biomolecular interactions underlying important cellular activities in various diseases, with a current emphasis on Alzheimer's disease.
Analysis of Dr. Song's recent publications shows a strong focus on Alzheimer's disease research, particularly examining TREM2 protein interactions with various ligands and ApoE variants. Her work combines computational biology with experimental validation to identify potential therapeutic targets and repurpose existing drugs. There is also significant research on vitamin D derivatives and their interactions with nuclear receptors, suggesting a broader interest in molecular pathways relevant to multiple disease conditions.
Dr. Song's research program is currently funded by:
- National Institutes of Health (NIH R01)
- National Science Foundation (NSF)
- Alzheimer's Drug Discovery Foundation
- UAB internal grants
Dr. Song leads a research group that utilizes integrated multiscale computational modeling and experimental approaches to investigate biomolecular interactions. Her methodology development for complex biological systems continues to be a significant focus, with the ultimate goal of identifying endogenous and exogenous small molecules to regulate biomolecular interactions underlying cellular activities in Alzheimer's disease, cancer, cardiovascular disease, dermatopathology, regenerative medicine and precision medicine.
