Yongke Lu

Dr. Yongke Lu is an Associate Professor at Marshall University's Department of Biomedical Sciences. His research focuses on alcohol-associated fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), with emphasis on CYP2A5 metabolism, oxidative stress mechanisms, and PPARα pathways.

Key investigations examine the protective role of CYP2A5 against liver injury, nicotine-enhanced ALD mechanisms, and the development of novel fibrosis models using CYP2A5/PPARα-deficient mice. Recent work explores peroxisome proliferation's role in ethanol metabolism and FGF21 signaling in adipose-liver interactions.

Methodologies incorporate molecular biology techniques, genetically modified mouse models, and metabolic pathway analysis. Published in journals including Hepatology, American Journal of Physiology, and Biochemical and Biophysical Research Communications.