Yong-Chen William Lu

Yong-Chen William Lu, PhD, is an Assistant Professor in the Department of Pathology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. His research program focuses on Cancer Biology, specifically developing T cell-based immunotherapies for metastatic malignancies. Dr. Lu utilizes cutting-edge single-cell genomic technologies to isolate neoantigen-specific T cell receptors, with applications in melanoma, gastrointestinal, breast, and brain cancers.

Research Interests: Dr. Lu's work spans basic and clinical research, emphasizing:

• Cancer Immunotherapy: Engineering T cells to target shared cancer antigens and patient-specific neoantigens.
• Translational Genomics: Applying single-cell sequencing to identify actionable immune targets.
• Health Disparities & Informatics: Optimizing therapeutic strategies for diverse patient populations.

His research keywords include: T cell biology, mutated antigens, and immunotherapy resistance mechanisms.

Publication Trends (2021-2025): Dr. Lu's 15 most recent articles concentrate on isolating mutation-specific T cell receptors (e.g., KRAS-G12D, p53), developing TCR-based therapies for solid tumors, and clinical trial design. Dominant themes include neoantigen discovery, high-throughput TCR screening, and mechanistic studies of T cell responses in hepatocellular carcinoma, glioblastoma, and HPV-associated neoplasia.