معرفی
Yizhou Hu is a Principal Researcher at the Department of Laboratory Medicine, Karolinska Institutet, Sweden, and holds a concurrent position as University Researcher at the Faculty of Medicine, University of Helsinki & Wihuri Institute, Finland. With extensive expertise in single-cell analysis and computational biology, Hu leads cutting-edge research at the intersection of cancer biology, neuroscience, and dermatology.
Dr. Hu's educational background includes a Ph.D. in Pathology (Oncology and Molecular Cell Biology) from the University of Helsinki (2017) and an M.Sc. in Genetics from the same institution (2011). Additional training includes postdoctoral research at Karolinska Institutet's Division of Molecular Neurobiology (2017-2022) supported by an SSMF fellowship.
Research interests center on two major themes: Developmental Plasticity in Nervous System Cancers focusing on glioblastoma and neuroblastoma mechanisms, and Immune Priming of Non-Immune Cells in Psoriatic Skin. Hu employs advanced methodologies including single-cell MultiOmics, spatial transcriptomics, deep-learning analytics (scCAMEL), human organoids, and genetically modified animal models to investigate cellular heterogeneity and disease mechanisms.
The publication record demonstrates consistent high-impact contributions across cancer biology, neuroscience, and dermatology. Recent work (2023-2025) shows increasing integration of machine learning with multi-omics approaches, particularly in neuroblastoma developmental plasticity, pain pathway characterization, and psoriasis inflammation mechanisms. The research spans basic science to translational applications with strong emphasis on cellular heterogeneity.
Scientific recognition includes:
- SSMF fellowship (2020-2022)
Dr. Hu has developed innovative computational tools including the scCAMEL suite (scCAMEL-SWAPLINE, scCAMEL-VICUNA, scCAMEL-EVO) for single-cell analysis, with publicly available datasets and visualization platforms for psoriasis research. Current work focuses on identifying cellular and molecular mechanisms driving high-risk neuroblastoma and glioblastoma, with emphasis on developmental trajectories that could inform targeted therapeutic approaches.
The research program maintains strong collaborative networks across Karolinska Institutet, University of Helsinki, and international institutions, with particular emphasis on neural crest-derived cancer lineages and skin immunology mechanisms.
