معرفی
Yi Yin is an Assistant Professor in the Department of Human Genetics at the University of California, Los Angeles (UCLA) School of Medicine. Her research focuses on understanding homologous recombination (HR), a major pathway for repairing double-strand breaks in DNA, which has critical implications in cancer biology, development, and genome stability.
Dr. Yin received her PhD and MS in Genetics and Genomics and Statistical Science, respectively, from Duke University in 2015. Her educational background has equipped her with a strong foundation in both biological mechanisms and quantitative analysis.
Her research interests center on building a probabilistic understanding of homologous recombination through the development of high-throughput single-cell sequencing technologies. The central vision of her lab is to develop tools that can predict genome fragility, identify epigenetic contexts regulating DNA breakage, determine how DNA repair gene variants affect repair processes, and understand the consequences of HR from single cells to individuals. She has developed the sci-L3 suite of single-cell sequencing technologies, which enables linear amplification of single-cell genomes at scale (up to 1 million cells) and supports multi-omics applications including whole-genome sequencing, targeted sequencing, and DNA/RNA co-assays.
Analysis of Dr. Yin's publication record reveals a consistent research trajectory focused on DNA repair mechanisms, particularly using yeast as a model organism to study homologous recombination. More recently, her work has expanded to include SARS-CoV-2 genomic epidemiology, demonstrating the versatility of her genomic technologies. Her publications show increasing impact, with several highly cited papers in top journals like Nature Biomedical Engineering, Molecular Cell, and Nature Biotechnology.
- Damon Runyon-Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation (2020-2022)
- Damon Runyon Fellowship Award, Damon Runyon Cancer Research Foundation (2016-2019)
Dr. Yin serves as Principal Investigator on NIH R35GM142511 "Understanding spontaneous mitotic crossover by single-cell multi-omics" (2021-2026), which supports her development of a full-fledged HR mapping platform. Her lab is working to characterize genome, tissue, and evolutionary variation in mitotic HR rates and machinery, with broader interests in genome-wide characterization of HR partner choice, cell-type variation in DNA repair pathway usage, construction of dense linkage maps in non-model organisms, and discovery of new DNA repair genes in unculturable microbes. The Yin Lab @ UCLA continues to push the boundaries of genomic technology development and its application to fundamental biological questions.
