معرفی
Yi Xu, PhD, is an Associate Professor at the Center for Infectious and Inflammatory Diseases within the Institute of Biosciences and Technology at Texas A&M University. He holds a PhD in biochemistry and molecular biology from the University of Texas Health Science Center at Houston (1998), followed by a postdoctoral fellowship at the same institution. His research focuses on bacterial-host interactions, particularly Streptococcus gallolyticus subsp. gallolyticus (Sgg) and its roles in infectious diseases and colorectal cancer (CRC). Key areas include Sgg’s mechanisms of gut colonization, tumor promotion, and immune evasion.
Dr. Xu’s lab investigates how Sgg disrupts intestinal barriers, enhances CRC risk (7-fold increased incidence in infected patients), and develops strategies to mitigate these pathologies. His work integrates in vitro models, mouse studies, and molecular biology to uncover bacterial virulence factors and host pathways. Notable contributions include elucidating Sgg’s type VII secretion system and extracellular matrix modulation roles in tumor growth.
Publications emphasize bacterial pathogenesis, spore persistence (e.g., Bacillus anthracis), and cellular entry mechanisms. His research bridges microbiology, oncology, and immunology, with implications for infectious disease treatment and cancer prevention. Dr. Xu leads the Xu Lab, fostering interdisciplinary approaches to combat microbial threats and associated diseases.
