معرفی
Yang Jiang is an Assistant Research Professor in the Department of Chemistry at Penn State, working in the O'Brien lab. He earned his B.S. in Applied Mathematics from Beijing University of Chemical Technology (BUCT) in 2012 and his Ph.D. in Chemical Engineering from BUCT in 2018 under Prof. Tianwei Tan's guidance. His research focuses on molecular modeling, biophysics, and protein structure-function relationships, particularly investigating protein folding kinetics and enzymatic activity using multi-scale simulations. His work explores how translation-elongation kinetics influence protein folding and how misfolding mechanisms can be addressed via computational and drug-design approaches.
Key research interests include protein misfolding mechanisms, entanglement effects in folded proteins, and the development of computational models for ions and metal cations. His studies often bridge theoretical predictions with experimental validation, such as using limited proteolysis mass spectrometry. He has also contributed to machine-learning applications in biophysical modeling and the rational design of nonbonded charge models for ions.
Publications highlight his exploration of protein misfolding intermediates, synonymous mutation effects, and the role of electrostatic forces in ribosomal processes. His work emphasizes understanding how misfolded proteins evade cellular quality control networks and remain soluble, offering insights into therapeutic strategies targeting these phenomena. Collaborations and computational tools developed in his lab advance understanding of protein dynamics and catalytic mechanisms.
