معرفی
Dr. Yan Zhao is a researcher at Newcastle University, specializing in cancer biology, pharmacology, and molecular interactions related to the MDM2-p53 pathway. Their work focuses on developing small molecule inhibitors for oncology applications, particularly in lymphomas and solid tumors.
- Key research areas: Cancer therapy, Protein-protein interactions, DNA repair mechanisms, and Drug development.
- Affiliated with experts like Professor Steve Wedge and Dr. Richard Noble.
Recent work highlights ASTX295 (2024), a next-generation MDM2 antagonist, and studies on dual metabolic inhibition in diffuse large B-cell lymphoma (2022). Earlier contributions include structural analysis of isoindolinones (2013-2014) and DNA-PK/ATM inhibitors for radiosensitization (2004-2006).
Collaborations span preclinical models, kinase inhibition, and molecular imaging techniques. Their publications emphasize therapeutic index optimization and apoptosis induction in tumor cells.