معرفی
Xufang Deng is an Assistant Professor in the Department of Physiological Sciences at Oklahoma State University's College of Veterinary Medicine. With a Ph.D. in Veterinary Virology from the Chinese Academy of Agricultural Sciences and postdoctoral training at Loyola University Chicago, Dr. Deng specializes in coronavirus-host interactions, vaccine design, and antiviral development. His lab employs advanced tools like
- Reverse genetics
- CRISPR-Cas9
- Transgenic mouse models
- ARTIC-Amplicon sequencing
Research interests include:
- Decoding viral immune evasion via Nsp15/EndoU
- Rational design of live-attenuated vaccines for porcine CoVs
- Developing protease inhibitors against SARS-CoV-2
- Monitoring SARS-CoV-2 adaptation in wildlife
Dr. Deng's recent work focuses on PLpro inhibitors (e.g., Jun12682) with oral efficacy against SARS-CoV-2 variants, including nirmatrelvir-resistant strains. His studies on Nsp15 mutations reveal critical roles in suppressing interferon pathways and enhancing viral fitness in lung cells. Collaborations with Rutgers University and University of Illinois Urbana-Champaign underpin his interdisciplinary approach.
Teaching activities include:
- Molecular Virology (CBSC-5110)
- Veterinary Biomedical Sciences Seminar (CBSC 6110)
- Molecular and Cellular Biology (CBSC 5103)
- PhD Research & Dissertation supervision
