معرفی
Xin Lu serves as Professor of Cancer Biology at the Nuffield Department of Medicine and Director of the Ludwig Institute for Cancer Research at the University of Oxford, while also holding a Supernumerary Fellowship at Magdalen College. Her research program focuses on identifying molecular mechanisms that suppress tumour growth and metastasis, with active collaborations between Oxford and Chinese research institutions targeting region-specific cancers.
Her academic foundation includes BS and Master's degrees earned in China, followed by PhD and postdoctoral training in the UK supported by a World Health Organization International Agency for Research on Cancer fellowship.
Professor Lu's research spans Cancer Biology and Molecular Biology with emphasis on tumour suppression mechanisms and cell fate determination. She established foundational knowledge of the p53 tumour suppressor protein (mutated in half of all cancers) and discovered the ASPP protein family that regulates p53 function. Her recent work investigates molecular causes of oesophageal and stomach cancers prevalent in Asian populations, and she identified the RaDAR nuclear import pathway with broad implications for disease mechanisms.
Her publication record features high-impact discoveries including the 2014 Cell paper on the RaDAR pathway, demonstrating how fundamental molecular research reveals novel biological mechanisms applicable to multiple disease contexts.
Her distinguished honors include:
- Honorary Fellow of the Royal College of Pathologists
- Member of European Molecular Biology Organisation (EMBO)
- Fellow of the Biological Society
- Fellow of the Academy of Medical Sciences
Professor Lu has trained numerous Chinese PhD students and postdoctoral fellows while securing long-term research support through the Ludwig Institute for Cancer Research's sustained funding model. She actively facilitates UK-China scientific exchange through Cancer Research UK's China Fellowships programme and Sino-British workshops.
Her laboratory operates within the Ludwig Institute for Cancer Research at Oxford's Old Road Campus, leveraging interdisciplinary collaboration with over 1,000 biomedical scientists across institutes including the Wellcome Trust Centre for Human Genetics and Cancer Research UK.
