Xin Lai

Dr. Xin Lai is a researcher at the Department of Systems Biology and Bioinformatics, University of Rostock, within the Faculty of Computer Science and Electrical Engineering. Their work combines mathematical modeling with systems biology to study microRNA regulation in cancer signaling pathways and aging-related processes.

Key research areas include:

• MicroRNA-mediated gene regulatory networks
• Mathematical analysis of p53 and E2F1 signaling
• Chemoresistance mechanisms in cancer
• Applications of nonlinear dynamics, sensitivity analysis, and multiscale hybrid modeling

Their publications span 2009-2018, with recent focus on miRNA cooperation in apoptosis regulation and inflammatory signaling. A notable 2012 best poster award highlighted their work on miR-146a/NF-κB interactions in lung inflammation. Collaborations include Prof. Olaf Wolkenhauer and Prof. Julio Vera.

Scientific contributions include:

• 2018: Mechanistic insights into miR-205-5p/342-3p in chemotherapy resistance
• 2016: Genotype-phenotype mapping for melanoma immune resistance
• 2014: Hybrid ODE-logic modeling of signaling-transcription crosstalk
• 2013: Kinetic analysis of E2F1-p73/DNp73-miR-205 network
• 2012: Computational framework for target hub gene repression by miRNAs