Xihong Lin

Xihong Lin is a Professor of Statistics at Harvard University and a Professor of Biostatistics at the Harvard T.H. Chan School of Public Health. She is a distinguished academic, holding membership in both the National Academy of Sciences and the National Academy of Medicine. Her research focuses on scalable statistical inference for big data, statistical machine learning, causal inference, and integrative data analysis, with applications in genomics, public health, and precision medicine.

Lin’s work addresses challenges in analyzing large-scale genomic and multi-ancestry data, including methods for rare variant association testing, ancestry-adjusted sample analysis, and scalable computing frameworks. Her contributions span biobank studies (e.g., UK Biobank, TOPMed) and clinical applications in lung cancer, cardiovascular health, and smoking cessation.

Her scientific awards reflect her leadership in statistical genetics and public health. Key research trends include leveraging single-cell sequencing for functional genomics, developing ensemble machine learning methods for health subtyping, and enhancing polygenic risk prediction across diverse populations. Lin’s methodologies prioritize interpretability and scalability, enabling impactful analyses of complex observational and genomic datasets.

• Awards: Member, National Academy of Sciences; Member, National Academy of Medicine

Her grants and advising efforts focus on interdisciplinary collaborations, bridging statistics, AI, and domain sciences. Lin leads initiatives to improve genomic data management and ethical use of federated data (e.g., FADI framework). She is affiliated with labs advancing statistical genetics and cloud-based workflows (e.g., STAAR workflow).