Xiaojun Shi

Xiaojun Shi is an Assistant Professor at Case Western Reserve University School of Medicine, affiliated with the Department of Medicine at MetroHealth Medical Center. His research focuses on receptor tyrosine kinase signaling, membrane protein interactions, and mitochondrial dynamics using advanced fluorescence spectroscopy techniques.

• Institution: Case Western Reserve University
• Department: Medicine (MetroHealth Medical Center)
• Position: Assistant Professor

Research interests include:

• EphA2 receptor tyrosine kinase signaling in cancer progression
• Lipid-protein interactions at membrane interfaces
• Time-resolved live-cell fluorescence spectroscopy applications
• Mitochondrial inner-membrane fusion mechanisms
• Development of pH-dependent peptides for tumor targeting

Recent publications analyze EphA2 multimeric assembly, cross-talk between EphA2 and EGFR, and mitochondrial fusion regulation by Opa1 isoforms. Collaborations include Bingcheng Wang, Adam Smith, and Francisco N. Barrera in studies of transmembrane interactions and cancer signaling pathways.

Technical expertise includes pulsed interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS), single-particle tracking, and in vitro reconstitution systems for membrane dynamics studies.