معرفی
Xiangfeng Lai is a Research Fellow in the Department of Materials Science and Engineering within Monash University's Faculty of Engineering. His work centers on antimicrobial nanotechnology and bacterial membrane interactions, primarily collaborating with Professor Hua-Kai Shen's research group.
His research focuses on developing novel nanoantibiotics targeting drug-resistant pathogens through advanced techniques like neutron reflectometry. Key areas include polysaccharide-targeting nanoparticles, lipid membrane reconstitution, and nitric oxide delivery systems against Gram-negative superbugs. Recent work explores structure-activity relationships of lipid nanoparticles and polymyxin-hexosome therapies.
Publications demonstrate strong interdisciplinary trends spanning nanomedicine, infectious disease, and structural biology. His 2024-2025 output shows concentrated work on antimicrobial mechanisms against LPS-deficient pathogens and cardiac-targeted nanotherapeutics, with publications in ACS journals and eLife.
Lai actively contributes to 8 major research projects (2020-2026), including Australian Nuclear Science and Technology Organisation collaborations. Current projects include 'Polysaccharide-targeting nanoantibiotics' (2024-2026) and neutron reflectometry studies on polymyxin therapies (2025).
He maintains strong technical partnerships with ANSTO and international collaborators, utilizing specialized facilities for membrane protein analysis. His methodology integrates materials science with microbiological validation to address antimicrobial resistance challenges.
