معرفی
Prof. W.G.J. (Wim) Hol is an Associate Professor at Utrecht University's Faculty of Science, specializing in Structural Biochemistry. His research focuses on protein crystallography, quinoprotein structures, and molecular dynamics of enzyme-inhibitor complexes.
- Primary affiliation: Utrecht University, Faculty of Science
- Research areas: Structural Biochemistry, Protein Dynamics, Metal Ion Interactions
- Email: w.g.j.hol@uu.nl / wgjhol@uu.nl
His work includes groundbreaking studies on:
- Quinoprotein methylamine dehydrogenase structure and cofactor reactivity
- Thermitase-eglin-c complex crystallographic refinement
- Calcium-dependent conformational changes in proteases
- Membrane protein crystallization techniques
Key methodological contributions:
- Restrained molecular dynamics for thermal motion analysis
- Two-crystal molecular dynamics comparisons
- Automated crystallization systems development
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