معرفی
William T. Gibson is a Professor in the Department of Medical Genetics at the University of British Columbia's Faculty of Medicine and a Senior Clinician Scientist at BC Children's Hospital Research Institute. He directs the Laboratory for Obesity Genetics and Indirect Calorimetry (LOGIC) and has made significant contributions to the field of medical genetics, particularly in identifying the genetic basis of rare disorders.
His research focuses on rare genetic disorders with implications for common diseases, particularly in the areas of epigenetics, overgrowth syndromes, and metabolic conditions. Gibson co-discovered Weaver syndrome (caused by EZH2 mutations) and Cohen-Gibson syndrome (caused by EED mutations), demonstrating how rare genetic variants can provide insights into common disease mechanisms. His work bridges clinical genetics with basic science to understand how epigenetic regulation affects development, growth, and metabolism.
Gibson's recent publications reveal a strong focus on epigenetic regulation through Polycomb repressive complexes, obesity-related genetics, and the connections between rare genetic disorders and common metabolic conditions. His research program combines patient recruitment with laboratory investigations to identify novel disease genes and understand their functional consequences.
- CIHR Clinician Scientist Phase 2 (2006-2014)
- Promoted to Full Professor at UBC (2018)
- CIHR Institute of Genetics Clinician-Investigator Award (2006-2008)
- Promoted to Associate Professor at UBC (2013)
Gibson supervises graduate students and postdoctoral fellows while maintaining active collaborations across multiple institutions. His research group includes graduate students, postdoctoral fellows, and research technicians working on various aspects of genetic disorders. Current research projects include studies of rare mutations that predispose to common diseases, particularly focusing on aneurysm risk, food intake, energy expenditure, and body growth.
His laboratory at BC Children's Hospital Research Institute serves as a hub for investigating the genetic basis of rare disorders and their implications for understanding common diseases in the general population.
