William J. Muller

William J. Muller is a Professor in the Department of Biochemistry at McGill University, with a primary research focus on the epidermal growth factor receptor (EGFR) family in breast cancer progression. He is affiliated with the Rosalind and Morris Goodman Cancer Center, where his lab investigates the molecular mechanisms of ErbB-2/neu overexpression and its role in tumorigenesis and metastasis. His research integrates Cre/Lox recombination systems to dissect signaling pathways in mammary tumor models.

Research Interests

• Role of receptor tyrosine kinases (EGFR family) in breast cancer
• Genetic and biochemical analysis of ErbB-2 signaling pathways
• Tumor microenvironment modulation (e.g., cytokines, metabolic adaptations)
• Preclinical modeling for therapeutic strategies

Publications Trends
Recent work emphasizes osteopontin, Chitinase 3-like-1, and AXL kinase in metastasis, alongside metabolic reprogramming (e.g., fatty acid oxidation, bioenergetics) and immunotherapy resistance mechanisms. His studies often leverage mouse models and CRISPR screening.

Scientific Awards

• Canada Research Chair in Molecular Oncology

Labs & Collaborations
The Muller Lab operates from the Cancer Research Building at McGill University, focusing on molecular oncology and translational cancer biology.