William Alexander

William Alexander is an Assistant Professor of Oncology at Roswell Park Comprehensive Cancer Center, specializing in Palliative Medicine. He holds dual MD and PhD degrees from the University of Rochester, with a focus on hepatobiliary cancer biology.

• BA: Chemistry, Maryville College (2010)
• PhD: Genetics, University of Rochester (2017)
• MD: University of Rochester (2019)
• Residency: Internal Medicine, SUNY Buffalo
• Fellowship: Palliative Medicine, SUNY Buffalo

His research bridges hepatobiliary cancer genetics and psychiatric palliative care, with recent work exploring ketamine and psychedelic therapies for cancer-related symptoms. Publications span molecular oncology (2016-2025) with a focus on cholangiocarcinoma mechanisms and inflammatory signaling pathways.

Scientific contributions include:

• Identification of Smad4's tumor-suppressive role in biliary cancers
• Development of novel intrahepatic cholangiocarcinoma models
• Mechanistic studies on ARID1A mutations in pancreatic cancer

Awarded Buffalo Spree Top Doctor (2025), he maintains affiliations with the American Board of Internal Medicine and professional societies including American College of Physicians.