معرفی
Walid Houry is a Professor at the University of Toronto, affiliated with the Faculty of Medicine's Department of Biochemistry and cross-appointed to the Department of Chemistry. His research focuses on cellular protein homeostasis, with emphasis on molecular chaperones and ATP-dependent proteases. Key projects include the R2TP chaperone complex, Clp proteolytic systems, and chaperone interaction networks. His lab explores these systems' roles in cancer and bacterial pathogenesis, aiming to develop novel therapeutics. Recent work includes antiviral strategies targeting protein homeostasis and antibiotic development targeting ClpP proteases.
- Research Highlights: R2TP-mediated complex assembly, ClpP protease dynamics, chaperone networks in stress response.
- Therapeutic Focus: Anticancer agents, antibacterial drugs, and pan-coronavirus antivirals.
Students in his lab include Chen Niu, Meijin Wu, and others, while recent publications (2024–2020) emphasize drug discovery and structural biology. The lab employs biophysical, proteomic, and bioinformatics approaches to unravel fundamental mechanisms and translational applications.
