Wade Regehr

Wade Regehr is the Bullard Professor of Neurobiology at Harvard Medical School, specializing in synaptic plasticity and cerebellar function. His research explores how synaptic properties influence behavior, with a focus on cerebellar circuitry and its role in neurological disorders. Regehr's lab investigates diverse topics, including neurotransmitter release mechanisms, cerebellar dysfunction in autism, and the functional roles of Purkinje cells and interneurons. Key interests include understanding how synaptic plasticity and cerebellar connectivity contribute to motor learning, sensory processing, and complex behaviors.

Research areas span molecular mechanisms of synaptic transmission (e.g., presynaptic calcium signaling, synaptotagmin isoforms) and circuit-level analysis of cerebellar pathways. His work often integrates electrophysiological, optogenetic, and computational approaches. The lab has uncovered novel roles for ephaptic coupling in Purkinje cell synchrony and identified critical pathways linking the cerebellum to forebrain regions. Recent studies highlight the cerebellum's broader influence beyond motor control, including emotional valence and social behaviors.

Publications emphasize cerebellar circuitry, synaptic plasticity mechanisms, and translational insights into neurological conditions. The Regehr Lab is located at 220 Longwood Ave, Boston, with ongoing projects exploring cerebellar dysfunction in autism and anxiety-related behaviors. Collaborative efforts include transcriptomic analyses of cerebellar cell types and functional studies of molecular layer interneurons.