Volodymyr Rybalchenko

Volodymyr Rybalchenko is a Research Fellow at the University of Texas Southwestern Medical Center (since 2009), Department of Physiology. His career includes roles at Yale University, University of North Texas Health Science Center, and institutions in France and Ukraine. His research focuses on ion channel biophysics, electrophysiological techniques, and cellular mechanisms in muscle, hearing, and neurobiology. Key contributions include discoveries on sodium channel mutations in muscle diseases, mechanosensitive channels in outer hair cells, and the role of presenilin in ryanodine receptor regulation.

• Affiliations: University of Texas Southwestern Medical Center (2009–Present), NIH/NIDCR (2010–2012), Yale University (2000–2004), and others.

Research interests span electrophysiology, ion channel dysfunction, muscle physiology, and molecular mechanisms of diseases. He pioneered techniques like microfluidic perfusion systems and lipid bilayer recordings. His work integrates biophysical modeling with experimental methods, addressing topics such as calcium signaling, mechanotransduction, and drug effects on ion channels.

Publications highlight studies on sodium channel mutations in periodic paralysis, TPC1 channel regulation, and estrogen receptor modulation of ryanodine receptors. Collaborations include NIH-funded projects and international teams. Techniques include patch-clamp, Ussing chamber assays, and custom microfluidics.