Vladimir Spiegelman

Vladimir Spiegelman is a Professor and THON Chair for Pediatric Cancer Research at the Penn State College of Medicine, affiliated with the Department of Pediatrics (Division of Hematology and Oncology) and the Department of Molecular and Precision Medicine. His research focuses on RNA-binding proteins, particularly CRD-BP and IGF2BP1, in the context of cancer biology, including colorectal cancer, melanoma, and neuroblastoma.

• Key research areas: Wnt signaling, mRNA stability, and targeted cancer therapies
• Active projects: Targeting ß-TrCP regulators to improve CRC response to chemotherapy (2024-2026)
• Grants: Funded by the National Cancer Institute and National Institute of Arthritis and Musculoskeletal and Skin Diseases

His recent publications (2024-2025) explore therapeutic agents like AVJ16 for lung carcinoma and mechanisms of IGF2BP1 in melanoma. Collaborations span global projects, with affiliations to the Penn State Cancer Institute and Neuroscience Institute.