معرفی
Vicki H. Wysocki is Professor and Chair at Georgia Institute of Technology, leading pioneering research in mass spectrometry and structural biology. Her work focuses on developing advanced techniques to study protein complexes, proteomics, and metabolomics, with her research group maintaining an active presence at major conferences including ASMS 2024 and preparations for ASMS 2025.
Her educational background includes:
- B.S. in Chemistry from Western Kentucky University (1982)
- Ph.D. in Chemistry from Purdue University (1987)
- Postdoctoral research at Purdue University (1987) and National Research Council/Naval Research Lab (1988-1989)
Dr. Wysocki's research spans four interconnected areas: (1) development of surface-induced dissociation (SID) on commercial mass spectrometry platforms; (2) native mass spectrometry-guided structural biology for studying large protein-protein complexes; (3) multi-omics approaches integrating proteomics and metabolomics with genomics for biomarker discovery; and (4) determination of peptide structures using IR action spectroscopy. Her work bridges analytical chemistry, biochemistry, and structural biology to address fundamental protein science questions.
Analysis of her recent publications reveals a strong focus on advancing native mass spectrometry techniques, particularly surface-induced dissociation, for structural characterization of protein complexes. Her work increasingly integrates multi-omics approaches to study bacterial pathogenesis, with emphasis on Salmonella infection mechanisms, while also exploring innovative instrumentation development for structural biology applications.
Dr. Wysocki has received numerous prestigious awards:
- 2022 Thomson Medal from the International Mass Spectrometry Foundation
- 2022 ACS Division of Analytical Chemistry Award
- 2017 ACS Field and Franklin Award for Outstanding Achievement in Mass Spectrometry
- 2016 OSU Excellence in Biochemistry Award
- 2009 Distinguished Contribution to Mass Spectrometry Award from ASMS
She actively mentors numerous graduate students and postdoctoral researchers, with current lab members including Kristie Baker, Yuan Gao, and Philip Lacey. Her research is supported by multiple NIH grants, enabling cutting-edge instrumentation development and biological applications. The Wysocki Group maintains strong collaborations across disciplines, particularly in microbiology and structural biology.
The Wysocki Research Group operates state-of-the-art mass spectrometry facilities at Georgia Tech, including specialized instrumentation for native mass spectrometry and surface-induced dissociation. The group actively develops new methodologies and maintains the website nativems.gatech.edu as a resource for the mass spectrometry community, demonstrating continued leadership at the intersection of technology development and biological discovery.
