معرفی
Prof. Valérie Anne McLin is a faculty member at the University of Geneva, affiliated with the Faculty of Medicine and based in the Department of Pediatric Specialties within the Department of Women, Children and Adolescents at the Hôpitaux Universitaires de Genève (HUG). She serves as a Group Leader conducting both clinical and basic research in pediatric liver diseases.
- Institution: University of Geneva
- Hospital Affiliation: Hôpitaux Universitaires de Genève (HUG)
- Academic Rank: Professor
- Research Focus: Pediatric hepatology and neurocognitive complications of chronic liver disease
Her research centers on understanding chronic hepatic encephalopathy in children, congenital portosystemic shunts, and long-term outcomes following pediatric liver transplantation. She leads a multidisciplinary research group that combines clinical observation with advanced molecular and metabolic analysis, including collaborations with EPFL and UNIL/CHUV.
Prof. McLin’s work integrates clinical research with basic science, focusing on the neurodevelopmental impact of liver disease in pediatric populations. Her projects include a prospective multicenter observational study on neurocognitive manifestations in children with chronic liver disease, the development of an International Registry of Congenital Portosystemic Shunts, and retrospective analyses using the Swiss Children's Liver Center database. In basic research, she investigates molecular changes in the developing brain using animal models of biliary atresia and explores the neurotoxic effects of bile acids and ammonia in organotypic brain cultures.
Although specific publications and scientific awards are not listed in the provided text, her research spans high-impact areas in pediatric hepatology and neurogastroenterology. She collaborates extensively across institutions to improve early diagnosis, develop standardized nomenclature for rare conditions, and identify risk factors for long-term complications.
Prof. McLin mentors a research team including laboratory technicians and clinical researchers. While formal advisees or students are not named, her leadership of research projects and supervision of team members indicate active academic mentoring. She is involved in quality improvement initiatives within the Swiss Children's Liver Center and contributes to national and international efforts in pediatric liver disease management.
Her laboratory operates at the intersection of clinical pediatrics and translational neuroscience, with ongoing projects analyzing metabolic brain changes via high-resolution magnetic resonance spectroscopy and investigating neuroprotective strategies. The team aims to establish early interventions to prevent irreversible neurocognitive deficits in children with chronic liver disease.
