Ute Koch

Ute Koch is a Researcher at the École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the School of Life Sciences (SV) and the Institute of Bioengineering (ISREC). She is part of the UPRAD group under Prof. Radtke, focusing on Notch signaling pathways in immune cell development, hematopoiesis, and cancer. Her work spans molecular biology, developmental biology, and immunology, with a particular emphasis on T cell maturation, B cell regulation, and the role of stromal niches in immune responses.

Education and Positions: Koch’s academic trajectory includes roles such as Research and Teaching Associate at EPFL, contributing to both research and teaching in life sciences. She has supervised PhD students including Mateusz Antoszewski and Delphine Tardivon, whose theses addressed Notch-driven leukemia and chronic lymphocytic leukemia mechanisms.

Research Interests: Her expertise encompasses the interplay between Notch signaling and immune cell fate decisions, including T-cell acute lymphoblastic leukemia (T-ALL), B-cell maturation, and the role of fibroblastic niches in orchestrating immune responses. She investigates Notch’s role in stem cell maintenance, tumor progression, and graft-versus-host disease.

Publications Overview: Koch’s research has been published in high-impact journals like the Journal of Experimental Medicine, Immunity, and Nature Communications. Recent work highlights Notch’s role in T-cell differentiation, B-cell positioning in the spleen, and leukemia pathogenesis. Her studies often integrate experimental models (e.g., murine systems) with molecular and cellular biology approaches.

Awards and Grants: While no specific awards are listed, her extensive publication record and collaborative projects indicate recognition within the field. Her work has been supported by grants related to immunology, stem cell biology, and cancer research.

Labs and Collaborations: She contributes to the Radtke Lab, focusing on Notch signaling’s multifaceted roles in health and disease. Her interdisciplinary approach bridges basic research with clinical implications in oncology and immune disorders.