Brandon J Burbach

Brandon J Burbach is a Researcher in the Department of Laboratory Medicine and Pathology at the University of Minnesota. His work bridges immunology, molecular biology, and biomedical engineering to advance cancer therapies and immune modulation strategies. Current projects include optimizing cryo-ablation for immune activation in murine models and investigating Notch signaling in graft-versus-host disease.

• Research Focus: CD8+ T cell biology, adoptive cell therapy, tumor immunology, and focal ablation techniques.
• Collaborations: Partnerships with institutions like Johnson & Johnson Enterprise Innovation and American Heart Greater Midwest Aff.

Research Themes: Dr. Burbach's studies explore mechanisms of T cell activation, immune checkpoint modulation, and tissue-resident memory cell formation. His work connects immunological signaling pathways (e.g., Notch, P2RX7) with therapeutic outcomes in prostate and breast cancer models.

Scientific Trends: Publications highlight interdisciplinary approaches combining

• Irreversible electroporation (IRE) with checkpoint inhibitors
• Adapter protein roles in NF-κB and integrin signaling
• Tumor antigen-specific immune responses

Key Techniques: Advanced imaging flow cytometry, murine and nonhuman primate models, and biomaterial scaffold design.