Ulrich G. Steidl

Ulrich G. Steidl, M.D., Ph.D., is a Professor in the Departments of Cell Biology, Oncology, and Medicine at Albert Einstein College of Medicine. He serves as Chair of the Department of Cell Biology and holds the Edward P. Evans Endowed Professorship for Myelodysplastic Syndromes. He is also Co-Director of the Blood Cancer Institute and Deputy Director/Associate Director for Basic Science at the Montefiore Einstein Comprehensive Cancer Center.

His research focuses on understanding the molecular mechanisms driving the transformation of hematopoietic stem cells (HSC) into pre-leukemic and leukemia stem cells (LSC), with a particular emphasis on transcription dynamics, epigenetic regulation, and targeted therapy development. Key areas include investigating how transcriptional plasticity and signaling mediators contribute to leukemia progression, and developing strategies to intercept cancer at the pre-leukemic stage.

Selected publications highlight breakthroughs in transcription factor activity modulation, glycan-based cell characterization, and MDMX-driven AML progression. His work advances translational computational biology and drug development for precision therapies targeting stem cell pathways.

Steidl’s contributions span the Montefiore Einstein Comprehensive Cancer Center and Blood Cancer Institute, emphasizing collaborative efforts in basic science and clinical translation. His research addresses critical gaps in understanding therapy resistance and disease relapse mechanisms.