Torsten Krude

Associate Professor Torsten Krude is a leading researcher in the Department of Zoology at the University of Cambridge, focusing on the regulation of chromosomal DNA replication in eukaryotic cells. He also serves as Vice-President of the Darwin College Boat Club, indicating his engagement beyond research.

His work primarily investigates how small non-coding RNAs (e.g., Y RNAs, stem-bulge RNAs) regulate DNA replication initiation. Key research themes include:

• Identifying replication proteins that interact with Y RNAs
• Characterizing functional domains of Y RNAs
• Elucidating Y RNA-chromatin interactions
• Mapping human DNA replication origins
• Exploring evolutionary conservation of Y RNA homologues

The 15 most recent publications highlight his expertise in DNA replication mechanisms, with a focus on Y RNAs, chromatin dynamics, and epigenetic regulation of replication origins. His lab has developed cell-free systems to study replication initiation and advanced methodologies like ini-seq for genome-wide origin mapping.