معرفی
Tomasz Nowakowski is an Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF) School of Medicine. He leads the UCSF Anatomy Lab, where his research integrates single-cell genomics, organoid technology, and computational approaches to study human brain development and disorders. His work spans neurogenesis, cortical patterning, and neuroimmune interactions, with a focus on neurodevelopmental conditions like autism and epilepsy.
His research interests center on:
- Developmental Neuroscience: Mechanisms of cortical layer formation, neural progenitor diversity, and thalamocortical connectivity
- Disease Modeling: Using cerebral organoids and assembloids to replicate neuropsychiatric disorders and brain malformations
- Microglial Biology: Roles in synaptic pruning, neuroinflammation, and prenatal brain development
- Tool Development: Creating viral vectors, CRISPR screens, and cloud-based platforms for neural circuit analysis
His publications emphasize:
- Advanced techniques for neural circuit mapping and single-cell profiling
- Molecular mechanisms underlying autism, schizophrenia, and epilepsy
- Evolutionary aspects of human brain development
- High-throughput methods for neurogenomic data integration
He directs an interdisciplinary team collaborating with neurology, genetics, and bioengineering experts. His lab is part of major consortia including PsychENCODE, contributing to large-scale brain cell atlases and open-source neuroinformatics resources.
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