معرفی
Tom Tullius is a Professor of Chemistry at Boston University, with joint appointments in Pharmacology and Experimental Therapeutics at the Boston University School of Medicine. He also serves as Director of the Boston University Bioinformatics Program. His research focuses on structural biology, biophysical chemistry, and genomics, particularly the development of hydroxyl radical footprinting to study DNA and RNA structures. Tullius earned his Ph.D. in Chemistry from Stanford University in 1979 and completed an NIH postdoctoral fellowship at Columbia University.
Research Interests: Tullius's work includes the structural analysis of DNA and RNA, evolutionary selection of DNA shape, and the ENCODE project. His lab introduced hydroxyl radical footprinting, a method widely used for studying nucleic acid structures and their interactions with proteins. Current projects involve mapping DNA shape at single-nucleotide resolution and developing high-throughput techniques for RNA structure analysis.
Awards and Honors:
- Ellison Medical Foundation Senior Scholar Award in Aging (2009–2013)
- Herbert A. Sober Award (1998)
- Fellow of the AAAS (1996)
- Searle Scholar (1984–1987)
Grants and Collaborations: His research has been supported by NIH and NSF grants, including studies on DNA structural motifs and ENCODE Consortium projects. The Tullius Lab collaborates with institutions like NIH and the National Human Genome Research Institute.
Labs and Teams: The Tullius Lab at Boston University develops chemical and computational tools for nucleic acid structure analysis. Projects include ORChID databases and GBshape genome browser tools for DNA structural annotations.
