Titia R. Oppewal

Dr. Titia R. Oppewal is a researcher at the Biomolecular Chemistry & Catalysis group within the Stratingh Institute of Chemistry at the University of Groningen's Faculty of Science and Engineering. Her work bridges biochemistry, molecular biology, and organic chemistry with a focus on therapeutic applications.

Dr. Oppewal's research centers on phage display technology and its application to macrocyclic peptide development. Her work explores how natural product-like macrocyclic structures can be evolved for improved pharmacological properties. Key research areas include:

• Development of novel cyclization strategies for peptide engineering
• Creation of asymmetric molecular scaffolds for drug discovery
• Application of phage display to select peptides with therapeutic potential
• Analysis of immune activation models and their implications for neurodevelopment

Her recent publications demonstrate a strong focus on using evolutionary approaches to improve drug candidates, particularly through the development of macrocyclic peptides with enhanced stability and binding properties. The work spans both chemical methodology development and biological applications, showing significant interdisciplinary collaboration across chemistry and life science disciplines at the University of Groningen.