Tine Goedhart

Tine Goedhart is a Researcher in the Department of Pediatrics at Erasmus University Medical Center Rotterdam, specializing in pharmacokinetics, haemophilia, and platelet research. Her work is closely associated with the SYMPHONY consortium, the Thrombocytopathy in the Netherlands (TiN) Study Group, and the OPTI-CLOT study group, focusing on thrombosis and haemostasis.

Her research spans Pharmacokinetics, Haemophilia A/B, Blood Clotting Factor 8, and Platelet Biochemistry. Key areas include optimizing factor concentrate dosing in haemophilia, developing rapid diagnostic tests for platelet disorders, and investigating endothelial cell heterogeneity in vascular diseases. Her work integrates pharmacological modeling with clinical applications to improve treatment strategies for bleeding disorders through:

• Pharmacokinetic-guided prophylaxis dosing
• Nanobody-based platelet agonist development
• Transcriptional profiling of endothelial colony-forming cells
• Population modeling for pediatric hemophilia B

Analysis of her 14 research outputs reveals dominant trends in thrombosis diagnostics, factor replacement therapy optimization, and pediatric pharmacokinetics, with strong emphasis on translational applications for hemophilia management and platelet function disorders.

Dr. Goedhart collaborates extensively with international consortia including SYMPHONY, TiN, and OPTI-CLOT, contributing to multi-center studies on haemophilia management and platelet function. While specific grant details are not provided, her research is embedded within these large-scale collaborative projects focused on advancing bleeding disorder treatments.

She actively participates in the SYMPHONY consortium and TiN study group, which drive innovation in thrombotic/bleeding disorder research through integrated pharmacokinetic and functional analyses across European institutions.