Tian Liu

Tian Liu, PhD, is an Assistant Professor in the Department of Pathology at Case Western Reserve University School of Medicine. He specializes in neurodegenerative diseases such as Alzheimer’s, Frontotemporal dementia, and ALS, with a focus on mitochondrial dysfunction and genetic mechanisms. His work integrates multi-omics approaches (proteomics, transcriptomics) and gene therapy strategies like viral vectors (AAV). Dr. Liu leads an NIH-funded lab investigating mitochondrial dynamics, organelle crosstalk, and neuroprotective pathways.

Education: PhD from Seoul National University (2014), postdoc training at USF Health Byrd Alzheimer’s Institute (2018).

Research Interests: Mitochondrial dysfunction in aging-related diseases, genetic variants in amyloid-β pathways, TDP-43-tau crosstalk in AD, and therapeutic strategies targeting mitochondrial quality control.

Recent NIH grants fund studies on mitochondrial mechanisms in neurodegeneration (R01AG086365, 2024–2029) and amyloid-β genetics (R03AG084948, 2024–2026). His lab employs patient-derived cellular models and mouse models to study mitochondrial phenotypes and develop therapies.