معرفی
Dr. Thu Annelise Nguyen serves as Professor of Toxicology at Texas Tech University's School of Veterinary Medicine and holds diplomate status with the American Board of Toxicology (DABT). Her research centers on gap junctional intercellular communication mechanisms in cancer formation, with significant contributions to 3D tumor organoid development for anticancer drug efficacy testing.
Her educational foundation includes a bachelor’s degree in molecular and cellular biology and a doctoral degree in toxicology from Texas A&M University. Key research breakthroughs demonstrate hydrocarbon compounds' inhibition of gap junction activity and substituted quinolines' ability to restore intercellular communication in breast cancer cells, leading to reduced tumor growth in animal models.
Current research expands into regulating gap junction dynamics within 3D heterogeneous tumor organoids. Future collaboration priorities focus on metabolic changes in cancer, estrogen-mediated responses, and adipocyte-epithelial interactions.
Notable recognitions include:
- 2020 PepGel Award in Application
- 2019 John Doull Award for outstanding contribution in toxicology
Her laboratory investigates how natural, environmental, and synthetic compounds disrupt cell-cell communication during carcinogenesis, with therapeutic applications in breast cancer treatment development.
