معرفی
Thomas Vierbuchen is an Assistant Professor in the Developmental Biology Program and Center for Stem Cell Biology at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, with affiliations to the Weill Cornell Graduate School of Medical Sciences. His research integrates stem cell biology, developmental neuroscience, and genomics to understand how neuronal diversity arises during brain development.
- University: Memorial Sloan Kettering Cancer Center
- School: Sloan Kettering Institute
- Department: Developmental Biology Program and Center for Stem Cell Biology
- Academic Rank: Assistant Professor
Dr. Vierbuchen's research focuses on the mechanisms of cell fate specification and gene regulation in the developing brain. Using directed differentiation of mouse and human pluripotent stem cells, his lab models neural development in vitro to study neural tube patterning, neuronal differentiation, and circuit formation. His work leverages genetic screens, genomics, and systems genetics approaches to dissect signaling pathways and transcriptional networks with high resolution.
Current research initiatives include developing novel brain organoid models, mapping evolutionary differences in brain development across mouse subspecies, modeling psychiatric and neurodegenerative diseases, and generating stem cell resources from genetically diverse mouse populations. These efforts aim to uncover the genetic basis of complex brain disorders and advance regenerative medicine.
Although no specific publications are listed, his research program is centered on cutting-edge techniques in stem cell engineering, single-cell genomics, and developmental neurobiology, indicating a strong focus on molecular and cellular mechanisms of neural development and disease.
Scientific awards received by Dr. Vierbuchen include:
- Josie Robertson Investigator Award, Sloan Kettering Institute (2018–2023)
- HHMI Fellow, Damon Runyon Cancer Research Foundation (2014–2018)
- David Hubel Award, Harvard Medical School (2017)
- Harold M. Weintraub Graduate Student Award (2013)
Dr. Vierbuchen leads an independent research laboratory and mentors postdoctoral fellows, such as Dr. Daniel Medina-Cano. His lab is supported by competitive funding, including the Josie Robertson Investigator Award, which provides significant research support for early-career faculty. While specific grants are not detailed, his HHMI Damon Runyon Fellowship and institutional investigator status reflect strong past and present funding success.
The Vierbuchen Lab operates within the Sloan Kettering Institute’s Developmental Biology Program and Center for Stem Cell Biology, leveraging interdisciplinary collaborations and core facilities for stem cell engineering, genomics, and imaging. The lab contributes to training PhD students in the Tri-Institutional Graduate Program and related fields.
