Thomas Seth Kupper

Thomas Seth Kupper, M.D. is the Thomas B. Fitzpatrick Professor of Dermatology at Harvard Medical School and serves as Head of the Department of Dermatology at Brigham and Women's Hospital in Boston. His work bridges clinical dermatology with cutting-edge immunological research, focusing primarily on skin immunology and cutaneous lymphomas.

Dr. Kupper's research interests center on T-cell biology, particularly resident memory T cells in the skin, cutaneous T-cell lymphoma (especially mycosis fungoides and Sézary syndrome), and the development of novel vaccination strategies. His laboratory investigates how skin vaccination can generate protective immune responses, particularly focusing on lung-tropic memory T cells. His work has significant implications for cancer immunotherapy, infectious disease prevention, and understanding immune memory in barrier tissues.

His recent publications highlight his leadership in understanding cutaneous lymphoma biology, treatment responses, and immune mechanisms. His work shows consistent NIH funding through 2028 for projects including skin vaccination strategies and optimizing T-cell responses to cancer through IL-1R1 signaling.

Dr. Kupper maintains an extensive collaborative network, particularly with colleagues at Brigham and Women's Hospital including Rachael Clark, Cecilia Larocca, and Nicole LeBoeuf. His work appears in high-impact journals across immunology, dermatology, and oncology.

His laboratory continues to advance our understanding of skin immunity and translate these findings into potential clinical applications for patients with cutaneous malignancies and immune-mediated skin disorders.