Thomas Renne

Thomas Renne is a Professor at the University Medical Center Hamburg-Eppendorf (UKE), where he serves in the Institute of Clinical Chemistry and Laboratory Medicine within the Medical School. His research spans hematology, immunology, and hepatology, with a particular focus on the intersection of coagulation, inflammation, and immune responses in liver diseases.

His research interests center on the contact phase system, neutrophil extracellular traps (NETs), and polyphosphate signaling in inflammatory and coagulative disorders. Renne's work has significant translational implications, particularly in understanding liver inflammation, primary sclerosing cholangitis (PSC), and bacterial infection responses. His laboratory employs advanced techniques including two-photon microscopy for intravital imaging of liver and other tissues.

Analysis of his publication trends reveals a strong focus on the molecular mechanisms connecting coagulation pathways with immune responses, particularly how Factor XII-driven coagulation traps bacterial infections and how NET formation contributes to inflammatory liver diseases. His work spans basic science investigations of polyphosphate signaling to clinical applications in liver disease and sepsis.

Notable research projects include:

• SFB 841 B8: Investigating the contact phase system in liver inflammation (2014-2020)
• SFB 841 - B8 - 3. Funding: Further exploration of the contact phase system (2018-2022)
• FU 742/4-2 TP06: The role of neutrophil extracellular traps in PSC pathogenesis (2019-2023)
• INST 152/876-1 FUGG: Development of a two-photon microscope for intravital microscopy (2020-2023)

Renne has secured significant funding from the German Research Foundation (DFG), including multiple projects within Collaborative Research Centers (SFB 841, SFB 1140, SFB 1192, SFB 1328) and Clinical Research Groups. His work demonstrates strong interdisciplinary collaboration across immunology, hepatology, and hematology research groups at UKE.

His laboratory is part of the UKE "Microscopy Imaging Facility" (UMIF), a registered DFG research infrastructure, where he contributes to advancing intravital microscopy techniques for studying inflammatory processes in liver and other tissues.