Thomas Daugbjerg Madsen

Thomas Daugbjerg Madsen serves as both an Assistant Professor and Guest Researcher at the Department of Cellular and Molecular Medicine within the Faculty of Health and Medical Sciences at the University of Copenhagen. He is affiliated with the Copenhagen Center for Glycomics, where he conducts cutting-edge research on peptide hormone glycosylation.

Dr. Madsen's primary research focus centers on the surprising discovery that numerous well-studied peptide hormones undergo glycosylation in the human body. His work has identified glycans on approximately one-third of known peptide hormones using sensitive mass spectrometry techniques. His research investigates how these glycovariants, which appear to be less potent but longer-circulating versions of non-glycosylated hormones, might serve as improved therapeutic agents for conditions like diabetes where current hormone treatments face limitations due to short half-lives.

His publication record demonstrates consistent high-impact contributions to glycobiology and related fields, with recent articles appearing in prestigious journals such as Nature Cell Biology, Journal of Biological Chemistry, and Nature Communications. His work spans multiple disciplines including biochemistry, endocrinology, neuroscience, and oncology, reflecting the broad implications of glycosylation research across biological systems.

Dr. Madsen's current research focuses on determining when peptide hormones become glycosylated in biological settings and investigating whether these glycopeptide hormones demonstrate extended effects in animal models compared to their non-glycosylated counterparts. His laboratory at the Copenhagen Center for Glycomics utilizes advanced mass spectrometry and biochemical approaches to study these phenomena.