معرفی
Ted Dawson, MD, PhD, is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases and a Professor in the Departments of Neurology, Neuroscience, Pharmacology and Molecular Sciences, and Physiology at the Johns Hopkins School of Medicine. He serves as Director of the Institute for Cell Engineering and co-leads the Neuroregeneration and Stem Cell Programs. His research is centered on understanding the molecular basis of neurodegeneration in Parkinson’s disease, stroke, and related disorders.
- Johns Hopkins University School of Medicine, Fellowship in Neurology (1993)
- Johns Hopkins University School of Medicine, Fellowship in Neuroscience (1992)
- Hospital of the University of Pennsylvania, Residency in Neurology (1990)
- University of Utah Health, MD and PhD in Pharmacology (1986)
- Montana State University, BS in Premedicine (1981)
Dr. Dawson’s research focuses on neuronal cell death and survival pathways, with a particular emphasis on the role of nitric oxide (NO), parthanatos, and the molecular mechanisms underlying Parkinson’s disease. His lab discovered the parthanatos cell death pathway, which involves PAR polymerase activation, AIF release, and MIF-mediated DNA fragmentation. He has made seminal contributions to understanding the function of parkin, LRRK2, DJ-1, and alpha-synuclein in PD pathogenesis. His work has led to the development of novel therapeutic strategies, including c-Abl inhibitors and the GLP-1 agonist NLY01.
His recent publications highlight advances in neuroinflammation, LRRK2 signaling, alpha-synuclein propagation via LAG3, and the role of innate immunity (e.g., STING pathway) in neurodegeneration. The research integrates molecular biology, genetics, and translational approaches to identify disease-modifying therapies.
Dr. Dawson has received numerous honors, including:
- Javits Neuroscience Investigator Award
- Election to the National Academy of Medicine
- Election to the National Academy of Inventors
- Clarivate Highly Cited Researcher
- Research.com Biology and Biochemistry Leader Award (2024)
- Fellow of the American Association for the Advancement of Science
He has mentored numerous trainees and collaborates extensively with labs such as the Kam, Kang, Mao, Sachdeva, Xu, and Ko labs. His research is supported by major grants from the NIH and private foundations, driving innovation in neuroprotection and regenerative medicine. Dr. Dawson continues to lead cutting-edge investigations into the mechanisms of neurodegeneration and the development of transformative therapies.
His lab is part of the Institute for Cell Engineering’s Neuroregeneration and Stem Cell Programs, where they use induced pluripotent stem cells and molecular screening to identify neuroprotective agents and survival pathways.
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