Tatiana Soboleva

Dr. Tatiana Soboleva is an Associate Professor in the Genome Sciences and Cancer Division at The Australian National University (ANU). She holds affiliations with the Shine-Dalgarno Centre for RNA Innovation and collaborates with the Chromatin and Translational Regulation group led by Prof. David Tremethick. Her research focuses on epigenetic mechanisms governing cell differentiation and cancer, particularly the role of histone variants like H2A.B in spermatogenesis and oncogenesis.

Dr. Soboleva completed her undergraduate studies in biochemistry at Moscow State University, earned a PhD in Molecular Medicine from ANU’s John Curtin School of Medical Research (JCSMR), and conducted postdoctoral research under Prof. Ian Young and Prof. David Tremethick. Her work revealed H2A.B’s dual role in chromatin regulation and RNA processing, with implications for male fertility and brain function.

Key research interests include the interplay between epigenetic regulators, gene expression, and disease. Her lab investigates how H2A.B modulates ribosome biogenesis in cancers like Hodgkin lymphoma and its role in spermatogenesis-specific processes. Collaborations emphasize translational epigenetics and cross-disciplinary approaches.

Her projects are supported by NHMRC grants and focus on developing therapies targeting H2A.B in cancer. She supervises research students and leads a team exploring histone-RNA interactions, chromatin dynamics, and epigenetic dysregulation in disease.