معرفی
Takashi Matsui, MD, PhD is Professor and Chair of the Department of Anatomy, Biochemistry and Physiology at the University of Hawaii at Manoa's John A. Burns School of Medicine (JABSOM). He holds dual appointments in Graduate Programs including Development and Reproductive Biology (DRB), Cell and Molecular Biology (CMB), and Molecular Bioscience and Bioengineering (MBBE). His career spans academic institutions in Japan and the U.S., including positions at Harvard Medical School and Beth Israel Deaconess Medical Center before joining UH in 2010.
Dr. Matsui's research focuses on cardiomyocyte survival mechanisms, particularly the role of mTOR signaling and ferroptosis in cardiac pathology. His work has defined ferroptosis as a critical regulated cell death pathway in ischemic heart disease and obesity-related cardiac dysfunction. Key contributions include identifying mTOR's protective role against iron-mediated cardiomyocyte death and elucidating ferroptosis propagation dynamics in myocardial injury models.
His laboratory has developed experimental frameworks for evaluating myocardial cell death mechanisms, contributing to diagnostic and therapeutic advancements in cardiovascular medicine. Matsui's translational research bridges basic science and clinical cardiology, addressing critical gaps in understanding cardiac injury and repair mechanisms.
