معرفی
Lei Huang, MD, MS, is an Associate Research Professor in the Department of Neurosurgery and the Physiology Division of the Basic Sciences at Loma Linda University School of Medicine. His academic work is centered on understanding and treating acute brain injuries through translational research.
Research Interests: Dr. Huang's research primarily focuses on neuroprotection in the context of stroke, neurosurgery, traumatic brain injury, and cardiac arrest. He utilizes clinically relevant animal models to explore the cellular and molecular mechanisms of brain injury and to develop innovative therapeutic strategies. His expertise spans neuroinflammation, neuronal ferroptosis, oxidative stress, blood-brain barrier integrity, and the role of immune cells in CNS pathology.
Publication Trends: An analysis of his recent publications (2023–2025) reveals a strong emphasis on identifying novel pharmacological targets and neuroprotective agents. His work frequently investigates signaling pathways (e.g., RhoA/YAP, 67LR/JNK/STAT1, IL-4R/STAT6/PPARγ) involved in cell death and inflammation following hemorrhagic and ischemic events. He has a significant body of work on molecular hydrogen as a therapeutic antioxidant and has explored treatments like proton beam therapy for meningiomas and receptor-targeted drugs for subarachnoid hemorrhage.
Grants and Projects: Dr. Huang has served as Principal Investigator (PD/PI) and investigator on several research grants. His projects include investigating the mechanisms of brain death-induced cardiac dysfunction, the management of atypical and anaplastic meningioma, and the use of hyperbaric oxygen for juvenile traumatic brain injury, demonstrating a broad yet interconnected research portfolio.
