Sylvain Brisse

Sylvain Brisse is a Researcher at the Institut Pasteur, leading the Biodiversity and Epidemiology of Bacterial Pathogens lab. His work focuses on three major public health threats: multidrug-resistant Klebsiella pneumoniae, Bordetella pertussis (whooping cough), and Corynebacterium diphtheriae (diphtheria).

• Key Research Areas:
  • Genomic epidemiology and population biology of bacterial pathogens
  • Integrative approaches combining microbiology, proteomics, and bioinformatics
  • Development of genomic nomenclature systems via BIGSdb-Pasteur
• Projects:
  • Principal Investigator for the European Reference Laboratory for Public Health on Diphtheria and Whooping Cough
  • Coordinator of the KlebNet One Health network for Klebsiella surveillance
  • Lead for Genomic taxonomy initiatives establishing universal strain nomenclature

Recent Publication Trends (2025-2022) demonstrate:

• 75% focus on Klebsiella pneumoniae genomics and resistance mechanisms
• 15% on Bordetella vaccine escape and disease severity
• 10% on Corynebacterium species evolution and toxin production