Susanna Goorden

Susanna Goorden is a researcher at the Erasmus Medical Center (Erasmus MC) within the Clinical Genetics department of the Clinical Chemistry division. Her work bridges biochemical and genetic research with clinical applications.

• Research Focus: Genetics, Biochemistry, and Molecular Biology
• Key Topics: Apolipoprotein E variants, Macrophage dysfunction, Tuberous Sclerosis, TOR pathway regulation

Goorden's research explores metabolic disorders, neurogenetics, and cellular signaling mechanisms through collaborations in Europe. Her recent publication in Genes (2025) examines inherited dyslipidemic splenomegaly as a macrophage storage disease linked to APOE variants.

In earlier work (2013-2015), she investigated:

• PAK2's role in TSC1/2 signaling independent of mTOR
• Neuronal function preservation in Rheb1 mutant mice
• Alpha CaMKII's temporal requirements in learning
• mTORC1 activity in Rheb-deficient fibroblasts

Her research has been cited extensively, with 35 citations for the 2014 Journal of Neuroscience paper and 37 citations for the 2015 Scientific Reports publication.