معرفی
Susan Fisher is a distinguished Professor at the University of California San Francisco (UCSF) School of Medicine, where she leads a multifaceted research program focused on placental development, trophoblast biology, and pregnancy complications. Her work bridges basic science and clinical applications, with particular emphasis on understanding the molecular mechanisms underlying normal and pathological pregnancy processes. As Principal Investigator on numerous NIH-funded projects since 1982, she has established herself as a leader in reproductive biology research.
Dr. Fisher's educational foundation includes:
- A.B. in Biology and Chemistry from Hope College, Holland, Michigan (1972)
- M.S. in Anatomy from University of Michigan, Ann Arbor (1973)
- Ph.D. in Anatomy from University of Kentucky, Lexington (1977)
- Postdoctoral training in Mass Spectrometry at University of Kentucky (1977-1982)
Her research program centers on three interconnected areas. First, she investigates the cellular mechanisms of trophoblast invasion during normal pregnancy, discovering how cytotrophoblasts regulate their invasive potential through balanced expression of pro- and anti-invasive molecules and how oxygen tension controls their differentiation. Second, her lab studies early human development using embryonic stem cell models, with recent work on apical-basal polarization and constructing human embryo fate maps. Third, she applies mass spectrometry approaches to proteome analyses, including salivary proteome mapping for disease diagnosis and environmental impact studies on placental development.
Analysis of her recent publications reveals a strong trend toward multi-omics approaches (transcriptomics, proteomics, lipidomics) to investigate environmental impacts on pregnancy. Her work increasingly examines how chemicals like pesticides, flame retardants, and bisphenol analogs affect placental function, with particular focus on molecular mechanisms linking environmental exposures to pregnancy complications like preeclampsia. This represents a significant shift toward translational environmental reproductive health research.
Dr. Fisher's scientific excellence has been recognized through numerous prestigious awards:
- Multiple NIH MERIT Awards (DE07244 in 2002 and HD076253 in 2014)
- UCSF Academic Senate Distinguished Teaching Award (1987)
- Pew Foundation Faculty Development Award (1988)
- UCSF Graduate Association Outstanding Mentor Award (2004)
- Frontiers in Reproduction Research Program Pioneer Award (2013)
- NIH State of the Art Lecture invitation
As a dedicated mentor and investigator, Dr. Fisher has maintained continuous NIH funding since 1982, directing major research initiatives including the UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center. Her laboratory has trained numerous graduate students and postdoctoral fellows, contributing significantly to the field through both scientific discoveries and人才培养. Her collaborative approach spans multiple disciplines, integrating cell biology, molecular techniques, and clinical perspectives to advance understanding of reproductive health.
Dr. Fisher leads a dynamic research team that combines traditional cell biology approaches with cutting-edge omics technologies. Her laboratory participates in several major collaborative initiatives at UCSF, particularly the PEEC Children's Center, which brings together environmental health scientists, obstetricians, and molecular biologists to investigate how environmental factors impact pregnancy outcomes. This interdisciplinary approach characterizes her research philosophy, bridging basic science with clinical applications to address critical issues in women's reproductive health.
