معرفی
Professor Suparna Sanyal is a leading molecular and structural biologist at Uppsala University, affiliated with the Department of Cell and Molecular Biology and the Uppsala RNA Research Centre (URRC). Her research centers on the ribosome, protein synthesis, and protein folding, with a strong focus on bacterial and eukaryotic systems, antibiotic mechanisms, and prion diseases.
Her research interests span protein synthesis, ribosome dynamics, translation factors, antibiotic resistance, and RNA biology. She investigates how GTP hydrolysis drives translation, how antibiotics target the ribosome, and how the ribosome itself contributes to protein folding (PFAR), with implications for diseases like tuberculosis and prion disorders. Her lab has pioneered in vitro reconstituted systems for studying translation and folding.
The recent publications highlight a strong trend in understanding antibiotic mechanisms (e.g., fusidic acid, arbekacin, thermorubin), ribosome dynamics using cryo-EM (e.g., in Giardia), and the role of ribosomal components in translation fidelity and termination. Her work bridges structural biology, microbiology, and disease mechanisms, particularly in mycobacteria and prion-related aggregation.
She leads the Sanyal Lab, which actively investigates ribosomal translocation, translation initiation/elongation/termination, and the biotechnological applications of synthetic translation systems.
