Sudarshan Anand

Dr. Sudarshan Anand is an Assistant Professor in the Department of Cell, Developmental and Cancer Biology at Oregon Health & Science University (OHSU) School of Medicine, a position he has held since March 2014. His research program focuses on how non-coding RNAs shape tumor responses to DNA-damaging therapies, with emphasis on breast and colorectal cancers.

Education:

• PhD in Immunology, Johns Hopkins University School of Medicine, 2007
• Postdoctoral Scholar, Moores Cancer Center, University of California, San Diego, 2007-2014

Research Interests:

Dr. Anand's laboratory investigates the role of microRNAs and non-coding RNAs in the tumor microenvironment, particularly in tumor blood vessels and immune cells. His work employs preclinical mouse models, human patient samples, and cell culture systems to develop therapeutic strategies and identify biomarkers for patient stratification. Key areas include radiation therapy response mechanisms, angiogenesis regulation, and nucleic acid sensing pathways in cancer.

Publication Trends:

Analysis of Dr. Anand's 15 most recent publications (2017-2024) reveals a consistent focus on microRNA regulation in colorectal cancer and tumor vasculature. His work bridges DNA damage response mechanisms with immunotherapy applications, showing increasing emphasis on early-onset cancer subtypes, microbiome interactions, and vascular normalization strategies to enhance drug delivery. Key recurring themes include RIG-I signaling, endothelial dysfunction, and combinatorial therapeutic approaches.

Lab and Team:

The Anand Lab utilizes multidisciplinary approaches to elucidate tumor microenvironment dynamics, with particular expertise in nucleic acid sensing pathways and endothelial cell biology. The team's research directly informs clinical translation efforts in radiation oncology and immunotherapy, focusing on biomarker discovery and therapeutic targeting of RNA-mediated mechanisms in cancer progression.