Subroto Ghose

Dr. Subroto Ghose is a Professor of Psychiatry at the University of Texas Southwestern Medical Center (UTSW), where he leads the Ghose Lab within the Schizophrenia Research Program. His medical training includes an MD from Delhi University/Maulana Azad Medical College (1991), psychiatry residency at Georgetown University School of Medicine (2001), and a neuropathology fellowship at the National Institutes of Health (2004). His research focuses on molecular mechanisms underlying schizophrenia, particularly glutamate receptor dysfunction and cannabis-psychosis interactions.

His primary research interests include:

• Schizophrenia pathophysiology with emphasis on prefrontal cortex and hippocampal dysfunction
• Glutamatergic neurotransmission, especially metabotropic glutamate receptors (mGluR2/3)
• Molecular consequences of adolescent cannabis exposure in psychosis development
• Neuropathological biomarkers using postmortem brain analysis and advanced neuroimaging

Analysis of his recent publications reveals a strong focus on translational schizophrenia research, combining molecular neuroscience with clinical psychiatry. His work demonstrates consistent investigation of glutamate signaling abnormalities, particularly NAAG-related pathways and COMT polymorphisms, while increasingly examining environmental risk factors like cannabis. The Ghose Lab collaborates extensively with the Tamminga Research Group on schizophrenia pathophysiology projects.

Key scientific contributions include:

• Identification of localized NAAG gene expression deficits in schizophrenia hippocampus
• Characterization of mGluR2/3 dysregulation as potential antipsychotic target
• Demonstration of adolescent cannabinoid vulnerability in schizophrenia models
• Development of 7 Tesla MRS techniques for neurochemical quantification

Dr. Ghose maintains an active research program mentoring junior scientists including Hanna, Shukla, and Jha. His lab receives funding for studies examining molecular alterations in schizophrenia and cannabis-psychosis relationships. The Ghose Lab operates within UTSW's Schizophrenia Research Program, utilizing advanced neuropathological and neuroimaging techniques to investigate disease mechanisms.